I have used inositol (and choline) in the clinic frequently over the past 10 years. Since many people that have Hashimoto’s are overweight and also have blood sugar regulation challenges, inositol has been very beneficial in helping my patients to heal. Together with choline, which helps with fatty acid metabolism in the liver, inositol can be a powerful healing agent.

Myo-inositol, a naturally occurring compound often mistaken for a B-vitamin, has been gaining attention for its potential benefits in supporting thyroid function, especially in people with Hashimoto’s thyroiditis. Though the body can produce this substance on its own, certain factors may lead to deficiencies, making supplementation beneficial. This article explores myo-inositol’s role in thyroid health, mental well-being, and metabolic function, with a focus on its relevance for Hashimoto’s.

What is Myo-Inositol?

Myo-inositol is a type of sugar alcohol found in human cells and various plant-based foods. While once considered part of the B-vitamin family, it is now known that the body synthesizes it, eliminating the need for dietary intake under normal conditions. However, some individuals may not produce enough to meet their physiological needs. Myo-inositol is naturally present in foods such as legumes, nuts, and fruits, with blueberries being a particularly rich source.

Myo-Inositol’s Impact on Thyroid Health

Hashimoto’s thyroiditis, an autoimmune condition, causes chronic inflammation in the thyroid, often leading to hypothyroidism. Recent research suggests that myo-inositol, especially when paired with selenium, may help regulate thyroid function and reduce immune system overactivity.

A study investigated the effects of supplementing with 600 mg of myo-inositol and 83 mcg of selenium daily over six months in people with autoimmune thyroid disease. The results showed a 31% decrease in thyroid-stimulating hormone (TSH) levels in the group taking both supplements, whereas those who took selenium alone saw no change. Additionally, thyroid antibodies were reduced by 44% in the myo-inositol and selenium group, compared to 42% in the selenium-only group. The combination also led to a 48% drop in thyroglobulin levels, while selenium alone resulted in a 38% reduction. Some participants even saw their thyroid antibody levels return to normal, indicating potential remission of Hashimoto’s.

This research suggests that myo-inositol, particularly in combination with selenium, may offer a natural way to support thyroid function and regulate the immune response in those with Hashimoto’s.

Myo-Inositol and Mental Health

People with Hashimoto’s often experience mood-related symptoms such as anxiety, depression, and obsessive-compulsive tendencies. Myo-inositol has been studied for its ability to improve mental well-being by positively influencing neurotransmitter activity.

Research has shown that supplementing with myo-inositol can reduce anxiety and improve overall mood in those with thyroid-related mental health struggles. Another study explored its use for obsessive-compulsive disorder (OCD), with participants taking 18 grams per day showing significant symptom improvement. Given its impact on brain chemistry, myo-inositol may be useful in managing the psychological symptoms associated with Hashimoto’s.

Myo-Inositol for Blood Sugar and Hormonal Balance

Hashimoto’s often coexists with other metabolic issues, such as insulin resistance and polycystic ovary syndrome (PCOS). Myo-inositol has been extensively studied for its role in improving insulin sensitivity and stabilizing blood sugar levels.

For individuals with PCOS, this supplement has been shown to help restore normal ovarian function, regulate menstrual cycles, and reduce insulin resistance. Since blood sugar imbalances can contribute to inflammation and worsen thyroid dysfunction, myo-inositol’s ability to support metabolic health may indirectly benefit thyroid function as well.

How Much Myo-Inositol Should You Take?

The ideal dosage varies depending on the intended use. In studies examining thyroid function, 600 mg of myo-inositol paired with 83 mcg of selenium daily has been shown to be effective. For mental health support, much larger doses—up to 18 grams per day—have been used in clinical research.

Myo-inositol is generally considered safe, though some people may experience mild digestive discomfort, dizziness, or headaches. Consulting a healthcare provider before starting supplementation is always recommended.

Final Thoughts

Myo-inositol appears to be a promising natural compound with benefits for thyroid function, mood stability, and metabolic health. For individuals with Hashimoto’s, supplementing with myo-inositol—especially alongside selenium—may help regulate the immune system, reduce thyroid antibodies, and support overall well-being. As always, it’s essential to tailor supplementation to individual health needs and consult a medical professional before making any major changes.